Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy.
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Fox Philip R, Keene Bruce W, Lamb Kenneth, Schober Karsten E, Chetboul Valérie, Luis Fuentes Virginia, Payne Jessie Rose, Wess Gerhard, Hogan Daniel F, Abbott Jonathan A, Häggström Jens, Culshaw Geoffrey, Fine-Ferreira Deborah, Cote Etienne, Trehiou-Sechi Emilie, Motsinger-Reif Alison A, Nakamura Reid K, Singh Manreet, Ware Wendy A, Riesen Sabine C, Borgarelli Michele, Rush John E, Vollmar Andrea, Lesser Michael B, Van Israel Nicole, Lee Pamela Ming-Show, Bulmer Barret, Santilli Roberto, Bossbaly Maribeth J, Quick Nadine, Bussadori Claudio, Bright Janice, Estrada Amara H, Ohad Dan G, Del Palacio Maria Josefa Fernández, Brayley Jennifer Lunney, Schwartz Denise S, Gordon Sonya G, Jung SeungWoo, Bove Christina M, Brambilla Paola G, Moïse N Sydney, Stauthammer Christopher, Quintavalla Cecilia, Manczur Ferenc, Stepien Rebecca L, Mooney Carmel, Hung Yong-Wei, Lobetti Remo, Tamborini Alice, Oyama Mark A, Komolov Andrey, Fujii Yoko, Pariaut Romain, Uechi Masami, Yukie Tachika Ohara Victoria
Аннотация
OBJECTIVES: To characterize/compare incidence rates, risk, and survival associated with noncardiovascular and all-cause mortality in AH and pHCM cats.
ANIMALS: A total of 1730 client-owned cats (722 AH, 1008 pHCM) from 21 countries.
METHODS: Retrospective, multicenter, longitudinal, cohort study. Long-term health data were extracted by medical record review and owner/referring veterinarian interviews.
RESULTS: Noncardiovascular death occurred in 534 (30.9%) of 1730 cats observed up to 15.2 years. Proportion of noncardiovascular death did not differ significantly between cats that at study enrollment were AH or had pHCM (P = .48). Cancer, chronic kidney disease, and conditions characterized by chronic weight-loss-vomiting-diarrhea-anorexia were the most frequently recorded noncardiovascular causes of death. Incidence rates/risk of noncardiac death increased with age in AH and pHCM. All-cause death proportions were greater in pHCM than AH (65% versus 40%, respectively; P < .001) because of higher cardiovascular mortality in pHCM cats. Comparing AH with pHCM, median survival (study entry to noncardiovascular death) did not differ (AH, 9.8 years; pHCM, 8.6 years; P = .10), but all-cause survival was significantly shorter in pHCM (P = .0001).
CONCLUSIONS AND CLINICAL IMPORTANCE: All-cause mortality was significantly greater in pHCM cats due to disease burden contributed by increased cardiovascular death superimposed upon noncardiovascular death.