Parkinsonism & related disorders · 2004
Dopamine-transporter imaging and visuo-motor testing in essential tremor, practical possibilities for detection of early stage Parkinson's disease.
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Schwartz Miguel, Groshar David, Inzelberg Rivka, Hocherman Shraga
Аннотация
BACKGROUND: Essential tremor (ET) is often an alternative diagnosis to Parkinson's disease (PD) and some ET patients may later develop PD. Unlike the former, PD patients have deficient visuo-motor coordination (VMC). Recently, we have attempted to exploit this difference in order to detect PD in ambiguous neurological cases.
OBJECTIVE: To assess the possibility of using VMC testing for screening ET patients prior to [123I]-FP-CIT SPECT imaging.
METHODS: Ten clinically diagnosed ET patients who showed deficient VMC were subjected to [123I-FP-CIT] SPECT imaging. We expected these patients to show subnormal striatal ligand uptake, as in PD.
RESULTS: We found decreased [123I]-FP-CIT uptake in 80% of the patients. A significant correlation between ligand uptake and VMC was observed.
CONCLUSIONS: Impaired VMC is a pertinent indication for further SPECT imaging in patients with ET, in order to establish a diagnosis of incipient PD.
OBJECTIVE: To assess the possibility of using VMC testing for screening ET patients prior to [123I]-FP-CIT SPECT imaging.
METHODS: Ten clinically diagnosed ET patients who showed deficient VMC were subjected to [123I-FP-CIT] SPECT imaging. We expected these patients to show subnormal striatal ligand uptake, as in PD.
RESULTS: We found decreased [123I]-FP-CIT uptake in 80% of the patients. A significant correlation between ligand uptake and VMC was observed.
CONCLUSIONS: Impaired VMC is a pertinent indication for further SPECT imaging in patients with ET, in order to establish a diagnosis of incipient PD.
Предметные рубрики MeSH
AgedDiagnosis, DifferentialDopamine Plasma Membrane Transport ProteinsEarly DiagnosisEssential TremorFemaleHumansIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMiddle AgedNerve Tissue ProteinsParkinson DiseasePsychomotor PerformanceTomography, Emission-Computed, Single-PhotonTropanes