Genetic testing and molecular biomarkers · 2019
A Comparative Study of ARHI Imprinted Gene Detection and Fine-Needle Aspiration Cytology in the Differential Diagnosis of Benign and Malignant Thyroid Nodules.
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Zou Dazhong, Wu Chengwei, Miao Jixuan, Shao Qing, Huang Wenlong, Huang Jianda, Wu Guihua, Zhang Qing
Аннотация
Aims: To compare fine-needle aspiration cytology (FNAC) with imprinted gene detection in the differential diagnosis of benign and malignant thyroid nodules. Methods: A total of 34 patients (35 cases of thyroid nodules) were examined using fine-needle puncture biopsy under ultrasound guidance, and the biopsy tissues were examined by cytologic examination and imprinted gene detection. Combined with postoperative pathology and follow-up results, the diagnostic value and consistency of the two methods were analyzed and compared. Results: The detection of benign and malignant thyroid nodules by ARHI imprinted gene had a high consistency with FNAC, and ARHI imprinted gene detection had a higher detection rate, sensitivity, and accuracy. Conclusions: Imprinted gene detection has high accuracy and sensitivity in the differential diagnosis of benign and malignant thyroid nodules. It provides a scientific reference for clinical treatment and should be incorporated into diagnostic protocols for thyroid tumor.
Предметные рубрики MeSH
Adenocarcinoma, FollicularAdolescentAdultAgedBiopsy, Fine-NeedleCarcinoma, Papillary, FollicularDiagnosis, DifferentialEpithelial CellsFemaleGenomic ImprintingGoiter, NodularHashimoto DiseaseHumansMaleMiddle AgedThyroid GlandThyroid NeoplasmsThyroid NoduleThyroiditis, SubacuteUltrasonographyYoung Adultrho GTP-Binding Proteins