Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe.
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Grehn Melanie, Mandija Stefano, Miszczyk Marcin, Krug David, Tomasik Bartłomiej, Stickney Kristine E, Alcantara Pino, Alongi Filippo, Anselmino Matteo, Aranda Ricardo Salgado, Balgobind Brian V, Boda-Heggemann Judit, Boldt Leif-Hendrik, Bottoni Nicola, Cvek Jakub, Elicin Olgun, De Ferrari Gaetano Maria, Hassink Rutger J, Hazelaar Colien, Hindricks Gerhard, Hurkmans Coen, Iotti Cinzia, Jadczyk Tomasz, Jiravsky Otakar, Jumeau Raphaël, Kristiansen Steen Buus, Levis Mario, López Manuel Algara, Martí-Almor Julio, Mehrhof Felix, Møller Ditte Sloth, Molon Giulio, Ouss Alexandre, Peichl Petr, Plasek Jiri, Postema Pieter G, Quesada Aurelio, Reichlin Tobias, Rordorf Roberto, Rudic Boris, Saguner Ardan M, Ter Bekke Rachel M A, Torrecilla José López, Troost Esther G C, Vitolo Viviana, Andratschke Nicolaus, Zeppenfeld Katja, Blamek Slawomir, Fast Martin, de Panfilis Ludovica, Blanck Oliver, Pruvot Etienne, Verhoeff Joost J C
Аннотация
The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions' experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs.