Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024
Prevalence of Chronic Liver Disease in Cholangiocarcinoma: A Meta-Analysis.
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Tham Ethan Kai Jun, Lim Ryan Yanzhe, Koh Benjamin, Tan Darren Jun Hao, Ng Cheng Han, Law Michelle, Cho Elina, Tang Nicole Shu Ying, Tan Claire Shiying, Sim Benedix Kuan Loo, Tan En Ying, Lim Wen Hui, Lim Mei Chin, Nakamura Toru, Danpanichkul Pojsakorn, Chirapongsathorn Sakkarin, Wijarnpreecha Karn, Takahashi Hirokazu, Morishita Asahiro, Zheng Ming-Hua, Kow Alfred, Muthiah Mark, Law Jia Hao, Huang Daniel Q
Аннотация
BACKGROUND AND AIMS: Chronic liver disease is a known risk factor for cholangiocarcinoma (CCA), but the proportion of people with CCA who have concurrent chronic liver disease is unclear. We aimed to evaluate the prevalence of chronic liver diseases in people with CCA.
METHODS: In this single-arm meta-analysis, we searched MEDLINE and EMBASE from inception to August 10, 2024, for articles in English containing data for CCA with and without chronic liver diseases. Data were pooled to obtain the prevalence of different chronic liver diseases, with further stratification by geographical location and tumor location.
RESULTS: In total, 118,068 individuals diagnosed with CCA were included, of whom 16,771 had chronic liver diseases. A pooled analysis of 109 studies determined that the prevalence of chronic liver disease was 25.23% (95% confidence interval [CI], 20.82%-30.23%; I2 = 99.0%), and 10.21% (7.75%-13.35%; I2 = 98.6%) of CCA patients had cirrhosis. Chronic liver diseases were associated more with intrahepatic CCAs, compared with extrahepatic CCAs (relative risk, 2.46; 95% CI, 2.37-2.55; P < .0001). This was observed across all etiologies of liver disease, except for primary sclerosing cholangitis, which was associated with extrahepatic CCAs (relative risk, 0.49; 95% CI, 0.43-0.57; P < .0001).
CONCLUSIONS: Around 1 in 4 people with CCA have chronic liver diseases, and 1 in 10 have cirrhosis.
METHODS: In this single-arm meta-analysis, we searched MEDLINE and EMBASE from inception to August 10, 2024, for articles in English containing data for CCA with and without chronic liver diseases. Data were pooled to obtain the prevalence of different chronic liver diseases, with further stratification by geographical location and tumor location.
RESULTS: In total, 118,068 individuals diagnosed with CCA were included, of whom 16,771 had chronic liver diseases. A pooled analysis of 109 studies determined that the prevalence of chronic liver disease was 25.23% (95% confidence interval [CI], 20.82%-30.23%; I2 = 99.0%), and 10.21% (7.75%-13.35%; I2 = 98.6%) of CCA patients had cirrhosis. Chronic liver diseases were associated more with intrahepatic CCAs, compared with extrahepatic CCAs (relative risk, 2.46; 95% CI, 2.37-2.55; P < .0001). This was observed across all etiologies of liver disease, except for primary sclerosing cholangitis, which was associated with extrahepatic CCAs (relative risk, 0.49; 95% CI, 0.43-0.57; P < .0001).
CONCLUSIONS: Around 1 in 4 people with CCA have chronic liver diseases, and 1 in 10 have cirrhosis.