Common data elements for observational studies in ocular toxoplasmosis: a Delphi consensus.
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Ошибки и ограничения
История · было → стало
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Rojas-Carabali William, Cifuentes-González Carlos, Goetz Kerry, Cicinelli Maria Vittoria, Thng Zheng Xian, Baxter Sally L, Tsui Edmund, Mahendradas Padmamalini, Biswas Jyotirmay, Androudi Sofia, Curi Andre Luiz Land, Ho Su Ling, Adán Alfredo, La Distia Nora Rina, Silveira Claudio, Nascimento Heloisa, Furtado João M, Muccioli Cristina, Mejía-Salgado Germán, Urzua Cristhian A, Garweg Justus G, Schlaen Ariel, Wei Xin, Balamurugan Sivaraman, Kharel Sitaula Ranju, Putera Ikhwanuliman, Rudzinski Marcelo, Babu Kalpana, Westcott Mark, Belfort Rubens, Smith Justine R, Gomez-Marin Jorge, Nguyen Quan Dong, Gupta Vishali, Agrawal Rupesh, de-la-Torre Alejandra
Аннотация
DESIGN: A set of CDEs was developed through a combination of a comprehensive literature review, a hybrid workshop, and a Delphi consensus process. This effort was led by an international panel of experts in OT to define a standardized CDE set for research and clinical purposes.
METHODS: A multidisciplinary steering committee identified an initial list of candidate CDEs through a targeted literature review. A panel of 30 international experts participated in a structured, one-round Delphi process to evaluate and refine these CDEs. Consensus was determined based on predefined thresholds for inclusion, exclusion, and modification.
RESULTS: A total of 139 CDEs were categorized across nine domains: Demographic and Background Information, Medical and Ocular History, Clinical Presentation, Clinical Findings, Lesion Characteristics, Diagnostics, Imaging Findings, Treatment and Interventions, and Outcomes. All 139 CDEs met the inclusion criteria, with 79.8% rated as "very important". The consensus underscores the importance of a comprehensive, standardized dataset for OT research.
CONCLUSIONS: This study establishes the first expert-derived standardized dataset requested for reporting OT outcomes, providing a framework to standardize data collection for future observational studies. Adopting these CDEs will enhance data comparability, improve meta-analyses, and strengthen the evidence base for clinical decision-making in OT. Future work will focus on real-world validation and refinement of this dataset.