Progressive angiomatosis, resembling human skeletal-extraskeletal angiomatosis, arising in multiple digits in two dogs.

Two dogs presented with progressive, expansile and invasive lesions on a hind paw. Case 1, a 10-year-old female Shetland sheepdog had diffusive and aggressive-looking lesions on the middle digits of the left hind paw. Radiographic examination showed invasion into and destruction of the underlying bone. A malignant tumour was suspected initially; however, histological features of atypical vascular proliferations without mitotic activity were consistent with progressive angiomatosis. Case 2, an 11-year-old female English springer spaniel presented with similar lesions in the same toes, also involving bone. Progressive angiomatosis was suspected clinically, as tumour cells were not detected by cytology and screening did not detect metastatic disease. Histopathology confirmed the diagnosis. Progressive angiomatosis is an uncommon non-malignant condition which should be considered as a differential diagnosis for radiographically lytic digital lesions.