Early advances of alpha1-antitrypsin precursor using the proteomic approach in gastric juice.

Evaluation of: Hsu PI, Chen CH, Hsieh CS et al.: alpha1-antitrypsin precursor in gastric juice is a novel biomarker for gastric cancer and ulcer. Clin. Cancer Res. 13(3), 876-883 (2007) [1] . The authors have identified the alpha1-antitrypsin precursor as a new protein marker of gastric cancer in gastric juice by 2D electrophoresis gel and mass spectrometric analyses. Three different pathologic classes of patients were considered with duodenal ulcer, gastric ulcer and gastric cancer and compared with healthy cases. alpha1-antitrypsin precursor was present, like the main peptide, in the specific band pattern, and seemed to be more expressed not only in advanced gastric cancer, but also in early forms of tumor. The study provides a fine contribution to this field of medicine, significantly correlating the alpha1-antrypsin precursor with gastric hypoacidity, gastric ulcer and gastric cancer. In addition, the utilization of gastric juice for biomarker recognition avoids the invasive resection of tissues. In conclusion, the research underlines, with an innovative and thorough approach, the role of the alpha1-antitrypsin precursor as a valid biomarker in gastric cancer and ulcers. However, it does not contribute to the advancement of research aimed at discovering the possible origin of the protein, and this could be the aim of future investigations.