Panta rhei, also drug eluting stent technology.

The Resolute zotarolimus eluting stent (ZES) is a next-generation durable polymer, thin-struts drug eluting stent. Although several randomized and observational studies have proven its safety and efficacy, long-term follow-up data are still limited. This prospective, multicenter, single arm study, showed favorable 5-year outcomes in patients undergoing Resolute ZES implantation, with considerably low rate of repeated revascularization and stent thrombosis. Data on long-term performance of next-generation drug eluting stents are of paramount importance to adequately inform decision-making in contemporary clinical practice.