JACC. Basic to translational science · 2019
Platelet Acetyl-CoA Carboxylase Phosphorylation: A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients.
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Kautbally Shakeel, Lepropre Sophie, Onselaer Marie-Blanche, Le Rigoleur Astrid, Ginion Audrey, De Meester de Ravenstein Christophe, Ambroise Jerome, Boudjeltia Karim Z, Octave Marie, Wéra Odile, Hego Alexandre, Pincemail Joël, Cheramy-Bien Jean-Paul, Huby Thierry, Giera Martin, Gerber Bernhard, Pouleur Anne-Catherine, Guigas Bruno, Vanoverschelde Jean-Louis, Kefer Joelle, Bertrand Luc, Oury Cécile, Horman Sandrine, Beauloye Christophe
Аннотация
Adenosine monophosphate-activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway. More interestingly, increased platelet AMPK-induced ACC phosphorylation is associated with the severity of coronary artery calcification as well as acute coronary events in coronary artery disease patients. Therefore, AMPK-induced ACC phosphorylation is a potential marker for risk stratification in suspected coronary artery disease patients. The inhibition of ACC resulting from its phosphorylation impacts platelet lipid content by down-regulating triglycerides, which in turn may affect platelet function.