The Nigerian postgraduate medical journal · 2026
Assessment of the Likelihood of Insulin Resistance and Type 2 Diabetes Mellitus Based on Serum Resistin Status among Nigerians.
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Okafor Johnbosco Chidozie, Odum Ehimen P, Okpara Henry C, Amadi Collins
Аннотация
BACKGROUND: Raised serum resistin is adjudged to increase the likelihood of insulin resistance (IR) and type 2 diabetes mellitus (T2DM) through multiple biochemical pathways.
AIMS: The current study assessed the likelihood of IR and T2DM among Nigerians based on serum resistin status.
MATERIALS AND METHODS: This case-controlled study was conducted at a tertiary hospital in southern Nigeria, among 100 T2DM patients matched with age/gender controls. Sociodemographic, anthropometric, clinical, and laboratory data, including serum resistin status, were collected using standard protocols. T2DM diagnosis was made using recommended guidelines. Statistical analyses were conducted using descriptive statistics, logistic regression models, and area under the curve (AUC) of the receiver-operating characteristic curve at a 95% confidence level (CI) and an alpha value of <0.05.
RESULTS: T2DM patients had higher mean values of body mass index (BMI), fasting plasma glucose (FPG), fasting serum insulin (FIN), homoeostatic model assessment of IR values (HOMA-IR) and serum resistin compared to controls (P < 0.05). Compared to the lowest quartile of serum resistin among T2DM patients, the likelihood of attaining IR status and T2DM risk increased with increasing quartiles of serum resistin, independent of matching factors (age/gender), occupation, BMI, FPG, FIN and HOMA-IR (Ptrend < 0.001). Increasing serum resistin had good predictive value on the likelihood of attaining IR status (AUC: 0.79; 95% CI: 0.72-0.85; P < 0.001) and T2DM risk (AUC: 0.89; 95% CI: 0.83-0.93; P < 0.001).
CONCLUSION: Current findings indicate a likelihood of IR and T2DM in association with increasing serum resistin, corroborating the role of resistin in T2DM through IR.
AIMS: The current study assessed the likelihood of IR and T2DM among Nigerians based on serum resistin status.
MATERIALS AND METHODS: This case-controlled study was conducted at a tertiary hospital in southern Nigeria, among 100 T2DM patients matched with age/gender controls. Sociodemographic, anthropometric, clinical, and laboratory data, including serum resistin status, were collected using standard protocols. T2DM diagnosis was made using recommended guidelines. Statistical analyses were conducted using descriptive statistics, logistic regression models, and area under the curve (AUC) of the receiver-operating characteristic curve at a 95% confidence level (CI) and an alpha value of <0.05.
RESULTS: T2DM patients had higher mean values of body mass index (BMI), fasting plasma glucose (FPG), fasting serum insulin (FIN), homoeostatic model assessment of IR values (HOMA-IR) and serum resistin compared to controls (P < 0.05). Compared to the lowest quartile of serum resistin among T2DM patients, the likelihood of attaining IR status and T2DM risk increased with increasing quartiles of serum resistin, independent of matching factors (age/gender), occupation, BMI, FPG, FIN and HOMA-IR (Ptrend < 0.001). Increasing serum resistin had good predictive value on the likelihood of attaining IR status (AUC: 0.79; 95% CI: 0.72-0.85; P < 0.001) and T2DM risk (AUC: 0.89; 95% CI: 0.83-0.93; P < 0.001).
CONCLUSION: Current findings indicate a likelihood of IR and T2DM in association with increasing serum resistin, corroborating the role of resistin in T2DM through IR.