The Role of Gli1+ Mesenchymal Stem Cells in Craniofacial Development and Disease Treatment.

OBJECTIVE

This review summarises the role of Gli1+ (Glioma-associated oncogene homologue 1) mesenchymal stem cells in craniofacial growth and development or tissue repair, and their application in the treatment of some diseases.

DESIGN

The search for this narrative review was conducted in PubMed and Web of Science using relevant keywords, including checking reference lists of journal articles by hand searching.

RESULTS

Gli1+ mesenchymal stem cells play an important role in the growth and development of the skull, tooth, periodontium and mandibular condyle. They can be applied to the treatment of pulp and periodontal diseases, temporomandibular joint osteoarthritis and other diseases.

CONCLUSIONS

Gli1+ mesenchymal stem cells are crucial for the development and repair of craniofacial tissue.