Biomarkers in medicine · 2026
Association between Castelli risk index and cardiovascular and cerebrovascular mortality in elderly type 2 diabetes mellitus patients.
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Wang Ruiang, Liu Yuan, Yang Xiaokun, Wang Yiming, Gu Liubao, Wang Huihui
Аннотация
BACKGROUND: The Castelli Risk Index (CRI) is an atherogenic index to assess cardiovascular disease risk. But the predictive value of CRI in assessing the risk of cardiovascular and cerebrovascular disease (CCVD)-related death in elderly patients with type 2 diabetes mellitus (T2DM) remains unclear.
METHODS: This retrospective cohort study analyzed clinical data from the SDTM Study, which began in 2005, including 888 patients aged ≥60 years with T2DM. Baseline lipid parameters and deaths related to CCVD during follow-up were recorded in hospital ward or outpatient clinic. The association between CRI and CCVD mortality was assessed by the Cox proportional hazards model. A competing-risk model was additionally employed to evaluate the association.
RESULTS: After a median follow-up of 7.62 years, 40 CCVD deaths occurred. The -CRI-I predicted CCVD deaths in elderly T2DM patients (HR: 1.35, 95% CI: 1.02 - 1.78, p = 0.038) after fully adjusting for age, gender, smoking, drinking, AST, ALT, creatinine, Fasting Blood Glucose, and use of statin. -Subgroup analysis showed that CCVD deaths were more strongly associated with CRI-I among females, those not taking statins, and those without coronary heart disease or hypertension.
CONCLUSIONS: CRI -can independently predict CCVD mortality in elderly T2DM patients.
METHODS: This retrospective cohort study analyzed clinical data from the SDTM Study, which began in 2005, including 888 patients aged ≥60 years with T2DM. Baseline lipid parameters and deaths related to CCVD during follow-up were recorded in hospital ward or outpatient clinic. The association between CRI and CCVD mortality was assessed by the Cox proportional hazards model. A competing-risk model was additionally employed to evaluate the association.
RESULTS: After a median follow-up of 7.62 years, 40 CCVD deaths occurred. The -CRI-I predicted CCVD deaths in elderly T2DM patients (HR: 1.35, 95% CI: 1.02 - 1.78, p = 0.038) after fully adjusting for age, gender, smoking, drinking, AST, ALT, creatinine, Fasting Blood Glucose, and use of statin. -Subgroup analysis showed that CCVD deaths were more strongly associated with CRI-I among females, those not taking statins, and those without coronary heart disease or hypertension.
CONCLUSIONS: CRI -can independently predict CCVD mortality in elderly T2DM patients.