Packed cells, platelet-rich plasma, and adenosine diphosphate in the production of occlusive vascular changes in lungs of rabbits.

An experimental study to simulate the lesions of primary pulmonary hypertension was under-taken in rabbits. Five groups were made, each having six animals and these were given separately packed cells (3 per cent suspension of homologous erythrocytes in physiologic saline), plasma rich in platelets, plasma without platelets, ADP solution, and normal saline injections biweekly for a period of three months. Clinical, electrocardiographic, and histologic examination of the lungs were made. It was noted that animals given packed cells, plasma rich in platelets, and ADP solution developed electrocardiographic changes and histologic lesions in the lungs suggestive of pulmonary hypertension.