The European baseline series in 10 European Countries, 2005/2006--results of the European Surveillance System on Contact Allergies (ESSCA).
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Uter Wolfgang, Rämsch Christiane, Aberer Werner, Ayala Fabio, Balato Anna, Beliauskiene Aiste, Fortina Anna Belloni, Bircher Andreas, Brasch Jochen, Chowdhury Mahbub M U, Coenraads Pieter-Jan, Schuttelaar Marie-Louise, Cooper Sue, Corradin Maria Teresa, Elsner Peter, English John S C, Fartasch Manigè, Mahler Vera, Frosch Peter J, Fuchs Thomas, Gawkrodger David J, Gimènez-Arnau Ana-Maria, Green Cathy M, Horne Helen L, Jolanki Riitta, King Codagh M, Krêcisz Beata, Kiec-Swierczynska Marta, Ormerod Anthony D, Orton David I, Peserico Andrea, Rantanen Tapio, Rustemeyer Thomas, Sansom Jane E, Simon Dagmar, Statham Barry N, Wilkinson Mark, Schnuch Axel
Аннотация
OBJECTIVES: To provide a current view on the spectrum of contact allergy to important sensitizers across Europe.
PATIENTS/METHODS: Clinical and patch test data of 19 793 patients patch tested in 2005/2006 in the 31 participating departments from 10 European countries (the European Surveillance System on Contact Allergies' (ESSCA) www.essca-dc.org) were descriptively analysed, aggregated to four European regions.
RESULTS: Nickel sulfate remains the most common allergen with standardized prevalences ranging from 19.7% (central Europe) to 24.4% (southern Europe). While a number of allergens shows limited variation across the four regions, such as Myroxylon pereirae (5.3-6.8%), cobalt chloride (6.2-8.8%) or thiuram mix (1.7-2.4%), the differences observed with other allergens may hint on underlying differences in exposures, for example: dichromate 2.4% in the UK (west) versus 4.5-5.9% in the remaining EU regions, methylchloroisothiazolinone/methylisothiazolinone 4.1% in the South versus 2.1-2.7% in the remaining regions.
CONCLUSIONS: Notwithstanding residual methodological variation (affecting at least some 'difficult' allergens) tackled by ongoing efforts for standardization, a comparative analysis as presented provides (i) a broad overview on contact allergy frequencies and (ii) interesting starting points for further, in-depth investigation.