A Parade of Persistent and Emerging Contact Allergens - A Clinical Update.

PURPOSE OF REVIEW: Clinical management of allergic contact dermatitis (ACD) is increasingly challenging due to the growing number of allergens, complex exposure patterns, and evolving regulatory frameworks. This review aims to provide clinicians with an updated overview of well-known as well as new and emerging allergens relevant to the diagnosis and management of ACD. RECENT FINDINGS: Recent literature highlights changing exposure patterns and the identification of several new and emerging allergens, particularly in rapidly expanding consumer markets such as cosmetics and products associated with medical devices. In addition, updated evidence has refined the clinical relevance of established allergen groups, including fragrances, metals, rubber chemicals, acrylates, and preservatives. Post-marketing surveillance of products and clinical patch test data continue to play an important role in detecting novel sensitizers and shifting exposure scenarios. Clinicians must remain vigilant, as exposure patterns continue to evolve with the introduction of new ingredients and products while established allergens persist. Ongoing surveillance and updated clinical awareness are essential to ensure accurate diagnosis and prevention of ACD.