Potential Role of ACE Polymorphisms in Severe Malaria: A Case Report.

Malaria, primarily caused by Plasmodium falciparum, remains a critical global health challenge, particularly in sub-Saharan Africa. Genetic factors such as angiotensin-converting enzyme (ACE) I/D polymorphism have been implicated in influencing malaria severity and outcomes. We report the case of a 40-year-old woman from Seychelles, residing in Ivory Coast, who developed severe P. falciparum malaria complicated by thrombosis. Laboratory findings revealed hyperparasitemia, acute kidney injury, and metabolic acidosis. Genetic testing through real time PCR identified the ACE I/D polymorphism, along with other thrombophilic variants such as MTHFR C677T and A1298C, suggesting a potential role in clinical course. This case aims to contribute to the debate about the role of ACE polymorphisms in malaria severity. Comprehensive studies are warranted to explore the genetic landscape in malaria-endemic regions and its implications for personalized treatment strategies.