Personalized medicine · 2025
The genetic association of IL-17A rs8193036 with the susceptibility to Alzheimer's disease.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Luo Yanni, Huang Jinpeng, An Zhongcheng, Zhang Xiaoping
Аннотация
AIM: This study aims to validate the relevance of IL-17A rs8193036 polymorphisms in susceptibility to Alzheimer's disease.
MATERIALS AND METHODS: A total of 210 healthy volunteers and 260 Alzheimer's disease patients were recruited. The genotype distribution of IL-17A rs8193036 was detected using the TaqMan-qPCR. The RT-qPCR was used to detect the expression of IL-17A in serum. The subjects of each genotype subgroup were statistically compared in terms of IL-17A expression and MMSE score. Logistic regression was used to analyze the independent risk factors for Alzheimer's disease.
RESULTS: The CC genotypes of IL-17A rs8193036 showed a high distribution in Alzheimer's disease patients (χ2 = 8.115, OR = 1.879, 95% CI = 1.213-2.910, p = 0.004). The expression of IL-17A was higher, and the ROC curves showed the favorable diagnostic significance of IL-17A in Alzheimer's disease. The serum level of IL-17A was higher in Alzheimer's disease patients with the CC genotype than the TT and CT genotypes. MMSE score of the CC genotype patients was lower than TT and CT genotypes. Gender, Education, MMSE score, IL-17A expression, and rs8193036 CC genotypes were risk factors for Alzheimer's disease.
CONCLUSION: The expression level of IL-17A is higher in Alzheimer's disease patients. The CC genotype of IL-17A rs8193036 is the causative genotype of Alzheimer's disease.
MATERIALS AND METHODS: A total of 210 healthy volunteers and 260 Alzheimer's disease patients were recruited. The genotype distribution of IL-17A rs8193036 was detected using the TaqMan-qPCR. The RT-qPCR was used to detect the expression of IL-17A in serum. The subjects of each genotype subgroup were statistically compared in terms of IL-17A expression and MMSE score. Logistic regression was used to analyze the independent risk factors for Alzheimer's disease.
RESULTS: The CC genotypes of IL-17A rs8193036 showed a high distribution in Alzheimer's disease patients (χ2 = 8.115, OR = 1.879, 95% CI = 1.213-2.910, p = 0.004). The expression of IL-17A was higher, and the ROC curves showed the favorable diagnostic significance of IL-17A in Alzheimer's disease. The serum level of IL-17A was higher in Alzheimer's disease patients with the CC genotype than the TT and CT genotypes. MMSE score of the CC genotype patients was lower than TT and CT genotypes. Gender, Education, MMSE score, IL-17A expression, and rs8193036 CC genotypes were risk factors for Alzheimer's disease.
CONCLUSION: The expression level of IL-17A is higher in Alzheimer's disease patients. The CC genotype of IL-17A rs8193036 is the causative genotype of Alzheimer's disease.