Cell · 2022

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.

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Dejnirattisai Wanwisa, Huo Jiandong, Zhou Daming, Zahradník Jiří, Supasa Piyada, Liu Chang, Duyvesteyn Helen M E, Ginn Helen M, Mentzer Alexander J, Tuekprakhon Aekkachai, Nutalai Rungtiwa, Wang Beibei, Dijokaite Aiste, Khan Suman, Avinoam Ori, Bahar Mohammad, Skelly Donal, Adele Sandra, Johnson Sile Ann, Amini Ali, Ritter Thomas G, Mason Chris, Dold Christina, Pan Daniel, Assadi Sara, Bellass Adam, Omo-Dare Nicola, Koeckerling David, Flaxman Amy, Jenkin Daniel, Aley Parvinder K, Voysey Merryn, Costa Clemens Sue Ann, Naveca Felipe Gomes, Nascimento Valdinete, Nascimento Fernanda, Fernandes da Costa Cristiano, Resende Paola Cristina, Pauvolid-Correa Alex, Siqueira Marilda M, Baillie Vicky, Serafin Natali, Kwatra Gaurav, Da Silva Kelly, Madhi Shabir A, Nunes Marta C, Malik Tariq, Openshaw Peter J M, Baillie J Kenneth, Semple Malcolm G, Townsend Alain R, Huang Kuan-Ying A, Tan Tiong Kit, Carroll Miles W, Klenerman Paul, Barnes Eleanor, Dunachie Susanna J, Constantinides Bede, Webster Hermione, Crook Derrick, Pollard Andrew J, Lambe Teresa, OPTIC Consortium, ISARIC4C Consortium, Paterson Neil G, Williams Mark A, Hall David R, Fry Elizabeth E, Mongkolsapaya Juthathip, Ren Jingshan, Schreiber Gideon, Stuart David I, Screaton Gavin R

Аннотация

On 24th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titers of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic Alpha, Beta, Gamma, or Delta are substantially reduced, or the sera failed to neutralize. Titers against Omicron are boosted by third vaccine doses and are high in both vaccinated individuals and those infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of the large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses and uses mutations that confer tight binding to ACE2 to unleash evolution driven by immune escape. This leads to a large number of mutations in the ACE2 binding site and rebalances receptor affinity to that of earlier pandemic viruses.

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.

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