bioRxiv : the preprint server for biology · 2021

Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.

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Dejnirattisai Wanwisa, Huo Jiandong, Zhou Daming, Zahradník Jiří, Supasa Piyada, Liu Chang, Duyvesteyn Helen M E, Ginn Helen M, Mentzer Alexander J, Tuekprakhon Aekkachai, Nutalai Rungtiwa, Wang Beibei, Dijokaite Aiste, Khan Suman, Avinoam Ori, Bahar Mohammad, Skelly Donal, Adele Sandra, Johnson Sile Ann, Amini Ali, Ritter Thomas, Mason Chris, Dold Christina, Pan Daniel, Assadi Sara, Bellass Adam, Omo-Dare Nikki, Koeckerling David, Flaxman Amy, Jenkin Daniel, Aley Parvinder K, Voysey Merryn, Clemens Sue Ann Costa, Naveca Felipe Gomes, Nascimento Valdinete, Nascimento Fernanda, Fernandes da Costa Cristiano, Resende Paola Cristina, Pauvolid-Correa Alex, Siqueira Marilda M, Baillie Vicky, Serafin Natali, Ditse Zanele, Da Silva Kelly, Madhi Shabir, Nunes Marta C, Malik Tariq, Openshaw Peter Jm, Baillie J Kenneth, Semple Malcolm G, Townsend Alain R, Huang Kuan-Ying A, Tan Tiong Kit, Carroll Miles W, Klenerman Paul, Barnes Eleanor, Dunachie Susanna J, Constantinides Bede, Webster Hermione, Crook Derrick, Pollard Andrew J, Lambe Teresa, OPTIC consortium, ISARIC4C consortium, Paterson Neil G, Williams Mark A, Hall David R, Fry Elizabeth E, Mongkolsapaya Juthathip, Ren Jingshan, Schreiber Gideon, Stuart David I, Screaton Gavin R

Аннотация

On the 24 th November 2021 the sequence of a new SARS CoV-2 viral isolate spreading rapidly in Southern Africa was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titres of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic as well as Alpha, Beta, Gamma, Delta are substantially reduced or fail to neutralize. Titres against Omicron are boosted by third vaccine doses and are high in cases both vaccinated and infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of a large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses, combining mutations conferring tight binding to ACE2 to unleash evolution driven by immune escape, leading to a large number of mutations in the ACE2 binding site which rebalance receptor affinity to that of early pandemic viruses.

Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.

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Аннотация