Clinical neurology and neurosurgery · 2022
Risk factors and their correlation with severity of cerebral microbleed in acute large artery atherosclerotic cerebral infarction patients.
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Chen Yanlin, Ye Maobin
Аннотация
OBJECTIVE: Risk factors and prognosis of cerebral microbleeding (CMB) complicated acute large artery atherosclerotic cerebral infarction (ALAACI) patients was controversial. Present study aimed to investigate the risk factors and severity of CMB among ALAACI.
METHODS: Totally 256 ALAACI patients receiving treatment in Central Hospital of Wuhan between May 2020 and September 2021 were included into this analysis. There were 152 simple ALAACI without CMB patients (simple group) and 104 ones with CMB (combined group). Based on the number of CMB, there were 19 (CMB≥10) patients in severe group, 34 (CMB=5-9) in moderate group, and 51 (CMB=1-4) in mild group. Logistic regression was used to explore the risk factors of CMB. Spearman rank analysis was conducted to investigate association of risk factors and severity of CMB.
RESULTS: There was no difference of sex, drinking, and smoking among the severe, the moderate, the mild, and the simple groups (P > 0.05). Age, rate of hypertension, lacunar cerebral infarction and prior cerebral infarction were all increased with the severity of CMB among these groups (P < 0.05). Logistic regression showed that the risk factors of CMB were hypertension, history of cerebral infarction, total cholesterol, and homocysteine. Spearman rank analysis revealed that hypertension, history of cerebral infarction, and homocysteine were positively correlated with the severity of CMB in ALAACI patients (r = 0.389, 0.154, 0.563, P = 0.003, 0.006, 0.012, respectively), while total cholesterol was negatively correlated with CMB (r = -0.321, P = 0.008).
CONCLUSIONS: Hypertension, history of cerebral infarction. homocysteine were positively associated with severity of CMB, and total cholesterol was negatively correlated with it in ALAACI patients.
METHODS: Totally 256 ALAACI patients receiving treatment in Central Hospital of Wuhan between May 2020 and September 2021 were included into this analysis. There were 152 simple ALAACI without CMB patients (simple group) and 104 ones with CMB (combined group). Based on the number of CMB, there were 19 (CMB≥10) patients in severe group, 34 (CMB=5-9) in moderate group, and 51 (CMB=1-4) in mild group. Logistic regression was used to explore the risk factors of CMB. Spearman rank analysis was conducted to investigate association of risk factors and severity of CMB.
RESULTS: There was no difference of sex, drinking, and smoking among the severe, the moderate, the mild, and the simple groups (P > 0.05). Age, rate of hypertension, lacunar cerebral infarction and prior cerebral infarction were all increased with the severity of CMB among these groups (P < 0.05). Logistic regression showed that the risk factors of CMB were hypertension, history of cerebral infarction, total cholesterol, and homocysteine. Spearman rank analysis revealed that hypertension, history of cerebral infarction, and homocysteine were positively correlated with the severity of CMB in ALAACI patients (r = 0.389, 0.154, 0.563, P = 0.003, 0.006, 0.012, respectively), while total cholesterol was negatively correlated with CMB (r = -0.321, P = 0.008).
CONCLUSIONS: Hypertension, history of cerebral infarction. homocysteine were positively associated with severity of CMB, and total cholesterol was negatively correlated with it in ALAACI patients.