[Hereditary disorders of hemostasis in obstetrics 1/2-Anesthesiological aspects of primary hemostasis].

Disorders of primary hemostasis affect platelet adhesion and aggregation and include von Willebrand disease (vWD), Glanzmann thrombasthenia (GT) and Bernhard-Soulier syndrome (BSS). The safe administration of epidural anesthesia procedures, such as peridural or spinal anesthesia (PDA/SpA) in patients with coagulation disorders requires a thorough weighing-up of the risk of bleeding, especially the risk of spinal epidural hematoma. The adequate management of postpartum hemorrhage (PPH) also requires exact knowledge of the underlying pathophysiology and the available hemostatic treatment options. This article provides an overview of selected hereditary coagulation disorders of primary hemostasis during pregnancy and elucidates the pathophysiological principles, clinical symptoms, diagnostic procedures and treatment strategies.