medRxiv : the preprint server for health sciences · 2026
Dengue and chikungunya virus transmission in Kinshasa, Democratic Republic of the Congo.
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Sendor Rachel, Edwards Jessie, Banek Kristin, Kashamuka Melchior Mwandagalirwa, Lessler Justin, Espinoza Daniel O, Castillo Izabella N, Vulu Fabien, Mvuama Nono, Bala Joseph A, Nkalani Marthe, Kihuma Georges, Atibu Joseph, Nseka Tommy, Thwai Kyaw L, Premkumar Lakshmanane, Dinglasan Rhoel R, Emch Michael, Juliano Jonathan J, Collins Matthew H, Tshefu Antoinette, Parr Jonathan B
Аннотация
Dengue (DENV) and chikungunya (CHIKV) are understudied in the Democratic Republic of the Congo (DRC) and across Africa despite evidence of transmission. We measured DENV and CHIKV IgG seroprevalences in Kinshasa Province, DRC, by antigen-capture ELISA, using dried blood spots from 2021. Force of infection (FOI) was estimated from age-stratified seroprevalences using Bayesian catalytic modeling. Among 1,250 participants, DENV IgG seroprevalence was 38.1% (95% CI: 34.5%-41.8%), increasing with age, and highest within peri-urban Kimpoko sites (54.9%). CHIKV IgG seroprevalence was 24.2% (95% CI: 21.1%-27.6%), increasing with age and comparable between peri-urban Kimpoko and rural Bu, with few seropositives in the city-center. DENV-CHIKV IgG co-occurrence was detected in 12.8% of participants. Time-varying FOI models provided best fit to age-stratified seroprevalences, with spatial variation detected. Sustained DENV and CHIKV circulation across Kinshasa highlights an under-appreciated transmission risk and underscores the need for strengthened arboviral surveillance in the DRC and surrounding region.