Journal of orthopaedics · 2019
Calcium sulphate mixed with antibiotics does not decrease efficacy against Cutibacterium acnes (formerly Propionibacterium acnes), in vitro study.
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Couture Anne, Lavergne Valéry, Sandman Emilie, Leduc Jean-Michel, Benoit Benoit, Leduc Stéphane, Rouleau Dominique M
Аннотация
BACKGROUND: This study explored the in vitro efficacy of antibiotics mixed with calcium sulfate (ACS) against Cutibacterium acnes (C. acnes).
METHODS: C. acnes isolates from orthopaedic infection sites were tested for antimicrobial susceptibility with ACS. Minimal inhibitory concentrations (MIC) were determined with a gradient diffusion method (Etest® strips).
RESULTS: When tested with Etest®, all 22 isolates were susceptible to penicillin, ceftriaxone, vancomycin, and two were resistant to clindamycin (MICs of 4 and 8 mg/L). Penicillin and rifampin had the largest inhibition zone diameters.
CONCLUSIONS: Antibiotics retained activity against C. acnes when mixed with calcium sulfate.
METHODS: C. acnes isolates from orthopaedic infection sites were tested for antimicrobial susceptibility with ACS. Minimal inhibitory concentrations (MIC) were determined with a gradient diffusion method (Etest® strips).
RESULTS: When tested with Etest®, all 22 isolates were susceptible to penicillin, ceftriaxone, vancomycin, and two were resistant to clindamycin (MICs of 4 and 8 mg/L). Penicillin and rifampin had the largest inhibition zone diameters.
CONCLUSIONS: Antibiotics retained activity against C. acnes when mixed with calcium sulfate.