The Annals of thoracic surgery · 2025
Neoadjuvant Chemotherapy-Immunotherapy in Non-Small Cell Lung Cancer: Can Positron Emission Tomography Scan Predict Complete Pathologic Response?
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Seitlinger Joseph, Salko Olivier, Bulgarelli Maqueda Luciano, Meng Andrew, Têtu Maxime, Desilets Antoine, Owen Scott, Shieh Benjamin, Wong Annick, Ofiara Linda, Agulnik Jason, Fiset Pierre-Olivier, Malo Julie, Blais Normand, Florescu Marie, Tehfe Mustapha, Ferraro Pasquale, Nasir Basil, Cools-Lartigue Jonathan, Najmeh Sara, Juneau Daniel, Elkrief Arielle, Ferri Lorenzo, Routy Bertrand, Liberman Moishe, Spicer Jonathan D
Аннотация
BACKGROUND: Several studies reported the survival benefit of neoadjuvant chemotherapy and immunotherapy (chemo-IO) for patients with operable non-small cell lung cancer vs chemotherapy alone. Uncertainty persists about real-world reproducibility of these findings as granular data outside clinical trials remain limited.
METHODS: We retrospectively analyzed prospectively maintained lung cancer registries and thoracic surgery databases from 2 high-volume Canadian thoracic oncology centers. Inclusion criteria were patients with proven clinical stage II-III non-small cell lung cancer who received at least 1 cycle of neoadjuvant chemo-IO. Survival curves were analyzed by the Kaplan-Meier test, and receiver operating characteristic curve analysis was performed to predict pathologic complete response (pCR) after neoadjuvant treatment according to standardized uptake value reduction.
RESULTS: A total of 78 patients were included, with a median follow-up of 12.3 months. Adverse events from neoadjuvant chemo-IO occurred in 54% of patients, of which 47% were grade 1-2 and 14% were grade 3. The pCR was 24% for a cohort in which programmed cell death protein ligand 1 tumor proportion score ≥50% was present in 46% of patients. A sensitivity analysis of 39 patients with positron emission tomography scans before and after chemo-IO found that a 70% reduction in maximal standardized uptake value significantly correlated with pCR (area under the curve, 0.89; P = .01).
CONCLUSIONS: This study supports the safety and short-term efficacy of neoadjuvant chemo-IO. Reduction in standardized uptake value on positron emission tomography scans was associated with pCR, indicating its potential as a surrogate biomarker pending further validation.
METHODS: We retrospectively analyzed prospectively maintained lung cancer registries and thoracic surgery databases from 2 high-volume Canadian thoracic oncology centers. Inclusion criteria were patients with proven clinical stage II-III non-small cell lung cancer who received at least 1 cycle of neoadjuvant chemo-IO. Survival curves were analyzed by the Kaplan-Meier test, and receiver operating characteristic curve analysis was performed to predict pathologic complete response (pCR) after neoadjuvant treatment according to standardized uptake value reduction.
RESULTS: A total of 78 patients were included, with a median follow-up of 12.3 months. Adverse events from neoadjuvant chemo-IO occurred in 54% of patients, of which 47% were grade 1-2 and 14% were grade 3. The pCR was 24% for a cohort in which programmed cell death protein ligand 1 tumor proportion score ≥50% was present in 46% of patients. A sensitivity analysis of 39 patients with positron emission tomography scans before and after chemo-IO found that a 70% reduction in maximal standardized uptake value significantly correlated with pCR (area under the curve, 0.89; P = .01).
CONCLUSIONS: This study supports the safety and short-term efficacy of neoadjuvant chemo-IO. Reduction in standardized uptake value on positron emission tomography scans was associated with pCR, indicating its potential as a surrogate biomarker pending further validation.