Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology · 2022
[The number of regulatory T cells in spleen and serum-related cytokines increase in mouse model of psoriasis induced by imiquimod].
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Zhou Yanmei, Li Huihui, Zou Weiyan, Qi Qi, Jiang Congjun
Аннотация
Objective To explore the role of regulatory T cells (Tregs) and its related cytokines in mouse model of psoriasis induced by imiquimod. Methods Female BALB/c mice were divided into control group and model group of psoriasis induced by imiquimod, with ten mice in each group. The psoriasis model was established by smearing imiquimod cream on the back of mice. HE staining was performed to observe the pathological changes of skin tissues. Flow cytometry was used to detect the number of Tregs in spleen and the levels of serum IL-10 and TGF-β1 was detected by ELISA. Results The mouse model of psoriasis was successfully established. Compared with the control group, the percentage of Tregs in spleen of the mouse model group significantly increased, and the levels of serum IL-10 and TGF-β1 also increased. Conclusion The number of Tregs and related cytokines increase in mouse model of psoriasis.