International journal of dentistry · 2022
Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Marques Meccatti Vanessa, de Souza Moura Larissa, Guerra Pinto Juliana, Ferreira-Strixino Juliana, Abu Hasna Amjad, Alves Figueiredo-Godoi Lívia Mara, Campos Junqueira Juliana, Marcucci Maria Cristina, de Paula Ramos Lucas, Carvalho Claudio Antonio Talge, Pucci Cesar Rogério, de Oliveira Luciane Dias
Аннотация
Radiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa); the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes "LED" on Candida albicans and Candida tropicalis in vitro; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa, curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α = 5%. It was found that C. longa, curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis. The extract of C. longa 100 mg/mL and curcumin 200 μg/mL do not show toxicity on Galleria mellonella model.