Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study.
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Domenighetti Cloé, Sugier Pierre-Emmanuel, Ashok Kumar Sreelatha Ashwin, Schulte Claudia, Grover Sandeep, Mohamed Océane, Portugal Berta, May Patrick, Bobbili Dheeraj R, Radivojkov-Blagojevic Milena, Lichtner Peter, Singleton Andrew B, Hernandez Dena G, Edsall Connor, Mellick George D, Zimprich Alexander, Pirker Walter, Rogaeva Ekaterina, Lang Anthony E, Koks Sulev, Taba Pille, Lesage Suzanne, Brice Alexis, Corvol Jean-Christophe, Chartier-Harlin Marie-Christine, Mutez Eugénie, Brockmann Kathrin, Deutschländer Angela B, Hadjigeorgiou Georges M, Dardiotis Efthimos, Stefanis Leonidas, Simitsi Athina Maria, Valente Enza Maria, Petrucci Simona, Duga Stefano, Straniero Letizia, Zecchinelli Anna, Pezzoli Gianni, Brighina Laura, Ferrarese Carlo, Annesi Grazia, Quattrone Andrea, Gagliardi Monica, Matsuo Hirotaka, Kawamura Yusuke, Hattori Nobutaka, Nishioka Kenya, Chung Sun Ju, Kim Yun Joong, Kolber Pierre, van de Warrenburg Bart P C, Bloem Bastiaan R, Aasly Jan, Toft Mathias, Pihlstrøm Lasse, Correia Guedes Leonor, Ferreira Joaquim J, Bardien Soraya, Carr Jonathan, Tolosa Eduardo, Ezquerra Mario, Pastor Pau, Diez-Fairen Monica, Wirdefeldt Karin, Pedersen Nancy L, Ran Caroline, Belin Andrea C, Puschmann Andreas, Hellberg Clara, Clarke Carl E, Morrison Karen E, Tan Manuela, Krainc Dimitri, Burbulla Lena F, Farrer Matt J, Krüger Rejko, Gasser Thomas, Sharma Manu, Elbaz Alexis, Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium
Аннотация
OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).
METHODS: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).
RESULTS: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).
CONCLUSIONS: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.