External validation of the international ICI-myocarditis registry risk score in a Japanese multicenter registry.

BACKGROUND

The International ICI-myocarditis Registry Risk Score predicts major adverse cardiotoxic events (MACE), but Japanese validation is limited.

METHODS AND

RESULTS

In a retrospective multicenter Japanese registry (23 hospitals), 88 patients were analyzed. MACE occurred in 25 (28.4%) and increased stepwise with higher scores (0: 10%, 1: 13%, 2: 32%, 3: 50%, 4: 67%, 5: 100%; P < 0.001). Discrimination was preserved (AUC 0.76, 95% CI 0.65-0.88); a cutoff ≥2 yielded 80.0% sensitivity and 60.3% specificity.

CONCLUSIONS

The score preserved discriminatory performance in Japanese cohort, but low scores did not exclude risk.