Journal of autoimmunity · 2025
Association between age groups and relapse of type 1 autoimmune pancreatitis: a large-scale retrospective cohort study.
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Xi Wenfeng, Feng Yunlu, Shi Wen, Li Jianing, Guo Tao, Bai Xiaoyin, Yang Aiming
Аннотация
BACKGROUND: Type 1 autoimmune pancreatitis (AIP) is a rare, immune-mediated pancreatic disease prone to relapse. The influence of age on relapse risk remains unclear. This study aimed to determine whether age at diagnosis is associated with disease relapse.
METHODS: We retrospectively analyzed 413 patients with type 1 AIP with over 2 years of follow-up. Patients were divided into two groups based on age at diagnosis: <60 years (n = 221) and ≥60 years (n = 192). Relapse rates were compared between groups. Logistic regression was used to assess the association between age group and relapse risk. Subgroup analyses by sex, diabetes, smoking, and heavy drinking were performed to test the stability of this association.
RESULTS: The median age was 58.0 years, with 79.4 % male patients and a median follow-up of 4.6 years. The overall relapse rate was 41.9 %, being higher in the <60 years group (46.2 %) than in the ≥60 years group (37.0 %). Age <60 years was significantly associated with increased relapse risk (OR = 1.7; 95 % CI: 1.1-2.7, P = 0.022) in multivariate logistic analysis. This effect was consistent across all subgroups examined.
CONCLUSIONS: In type 1 AIP, age<60 years increases the risk of disease relapse. Age should be considered in long-term disease management.
METHODS: We retrospectively analyzed 413 patients with type 1 AIP with over 2 years of follow-up. Patients were divided into two groups based on age at diagnosis: <60 years (n = 221) and ≥60 years (n = 192). Relapse rates were compared between groups. Logistic regression was used to assess the association between age group and relapse risk. Subgroup analyses by sex, diabetes, smoking, and heavy drinking were performed to test the stability of this association.
RESULTS: The median age was 58.0 years, with 79.4 % male patients and a median follow-up of 4.6 years. The overall relapse rate was 41.9 %, being higher in the <60 years group (46.2 %) than in the ≥60 years group (37.0 %). Age <60 years was significantly associated with increased relapse risk (OR = 1.7; 95 % CI: 1.1-2.7, P = 0.022) in multivariate logistic analysis. This effect was consistent across all subgroups examined.
CONCLUSIONS: In type 1 AIP, age<60 years increases the risk of disease relapse. Age should be considered in long-term disease management.