A Novel IFIH1 Mutation Causing Hyper-IgE Syndrome Presenting as Childhood Erythroderma: Case Report.

Erythroderma in the pediatric population is an uncommon yet challenging condition. The etiologies encompass a wide variety of illnesses, including seborrheic dermatitis, infections, inborn errors of immunity, ichthyosiform disorders and metabolic abnormalities. Hyper-immunoglobulin E syndrome (HIES) occurs due to various known genetic variants, e.g., STAT3 (signal transducer and activator of transcription-3), IL6R (Interleukin-6 receptor) deficiency and others, with an extensive list of features including erythroderma in childhood. Our case describes association of a possible novel mutation in IFIH1 (interferon-induced with helicase C domain 1) gene with HIES, which may aid in deciphering the complex nature of this disorder.