[Characteristics of functional status of the autonomic nervous system in patients with diabetes mellitus].

AIM: To evaluate prognostic significance of autonomic nervous system (ANS) dysfunction in patients with diabetes mellitus (DM).

MATERIAL AND

METHODS

The examination covered 51 DM type 1 patients aged 18 to 43 years with DM history from 6 months to 31 years. ANS function was assessed by spectral analysis of cardiac rhythm with calculation of indices of rhythm "rigidity", centralization and activity of subcortical centers.

RESULTS

DM progression and development of its late complications were accompanied with dissociation of tonicity of the sympathetic and parasympathetic ANS components, augmentation of regulatory systems tension. Evidence was obtained for correlation of relative values of SW1 power with severity of DM (r = 0.88) and its microvascular complications (r = 0.70). Decreased power of MW2(%) in the tilt test predicts development of orthostatic hypotension.

CONCLUSION

Involvement in the regulation of the central contour of ANS management reflects adaptation failure and is prognostically significant.