Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi · 2011
[Monitoring of Mycobacterium tuberculosis infections in Iaşi County in 2009].
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Luncă Cătălina, Enache Ecaterina, Olaru Simona Peter, Diculencu Daniela, Iancu Luminiţa Smaranda
Аннотация
UNLABELLED: Tuberculosis is a major public health problem worldwide. Our study aimed to investigate epidemiological and demographic characteristics of tuberculosis infection and resistance to antituberculous drugs in Iasi County in 2009.
MATERIAL AND METHOD: We have analysed the epidemiological parameters for 687 patients with pulmonary tuberculosis, new cases confirmed by microscopy and cultivation on Lowenstein Jensen. First and second-line antituberculous susceptibility testing was done for 130 strains, using agar proportion method and absolute-concentration method.
RESULTS: The number of new cases of tuberculosis was higher in rural areas and in males 41-50 years old (sex ratio=2.22). The proportion of positive cases in microscopy was 81.51%. Drug resistance was as follows: 16 isolates (12.3%) to isoniazid, 5 (3.84%) to rifampin, 2 (1.53%) to ethambutol, 2 (1.53%) to streptomycin and 4 (3.07%) were multidrug-resistant.
CONCLUSIONS: In this study we found high resistance rates to isoniazid, streptomycin and ethambutol. This requires increasing efficiency of tuberculosis diagnosis and susceptibility testing.
MATERIAL AND METHOD: We have analysed the epidemiological parameters for 687 patients with pulmonary tuberculosis, new cases confirmed by microscopy and cultivation on Lowenstein Jensen. First and second-line antituberculous susceptibility testing was done for 130 strains, using agar proportion method and absolute-concentration method.
RESULTS: The number of new cases of tuberculosis was higher in rural areas and in males 41-50 years old (sex ratio=2.22). The proportion of positive cases in microscopy was 81.51%. Drug resistance was as follows: 16 isolates (12.3%) to isoniazid, 5 (3.84%) to rifampin, 2 (1.53%) to ethambutol, 2 (1.53%) to streptomycin and 4 (3.07%) were multidrug-resistant.
CONCLUSIONS: In this study we found high resistance rates to isoniazid, streptomycin and ethambutol. This requires increasing efficiency of tuberculosis diagnosis and susceptibility testing.
Предметные рубрики MeSH
AdolescentAdultAntitubercular AgentsChild, PreschoolDrug Resistance, BacterialDrug Resistance, Multiple, BacterialFemaleHumansIncidenceInfantInfant, NewbornMaleMicrobial Sensitivity TestsMiddle AgedMycobacterium tuberculosisPopulation SurveillancePovertyRetrospective StudiesRisk FactorsRomaniaRural PopulationSex DistributionSex FactorsTuberculosis, PulmonaryUrban Population