Spectral Doppler analysis of parathyroid adenoma: correlation between resistive index and serum parathyroid hormone concentration.

OBJECTIVE

The purpose of this study was to evaluate the correlation between spectral wave analyses by measuring the resistive index and serum intact parathyroid hormone (iPTH) concentration in primary hyperparathyroidism.

SUBJECTS AND

METHODS

From March 2008 to April 2012, 46 consecutively registered patients underwent color and spectral Doppler ultrasonography for determination of vascularity and vascular resistance of parathyroid adenoma. The color Doppler sonographic findings were compared with methoxyisobutylisonitrile (MIBI) scintigraphic findings, serum iPTH concentration, and the volume of the gland.

RESULTS

The mean resistive index in parathyroid adenoma was 0.69 ± 0.12. The study showed a strong negative relation between resistive index and serum iPTH concentration. There was a significant negative relation between the volume of the gland and the resistive index.

CONCLUSION

There is a relation between degree of perfusion in parathyroid adenoma and serum iPTH concentration. Resistive index may be an objective alternative parameter for determining the vascularity of adenoma for monitoring of response to alcohol ablation therapy and medical management.