Медицинская библиотека · Nature communications · 2014
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
Postmus Iris, Trompet Stella, Deshmukh Harshal A, Barnes Michael R, Li Xiaohui, Warren Helen R, Chasman Daniel I, Zhou Kaixin, Arsenault Benoit J, Donnelly Louise A, Wiggins Kerri L, Avery Christy L, Griffin Paula, Feng QiPing, Taylor Kent D, Li Guo, Evans Daniel S, Smith Albert V, de Keyser Catherine E, Johnson Andrew D, de Craen Anton J M, Stott David J, Buckley Brendan M, Ford Ian, Westendorp Rudi G J, Slagboom P Eline, Sattar Naveed, Munroe Patricia B, Sever Peter, Poulter Neil, Stanton Alice, Shields Denis C, O'Brien Eoin, Shaw-Hawkins Sue, Chen Y-D Ida, Nickerson Deborah A, Smith Joshua D, Dubé Marie Pierre, Boekholdt S Matthijs, Hovingh G Kees, Kastelein John J P, McKeigue Paul M, Betteridge John, Neil Andrew, Durrington Paul N, Doney Alex, Carr Fiona, Morris Andrew, McCarthy Mark I, Groop Leif, Ahlqvist Emma, Welcome Trust Case Control Consortium, Bis Joshua C, Rice Kenneth, Smith Nicholas L, Lumley Thomas, Whitsel Eric A, Stürmer Til, Boerwinkle Eric, Ngwa Julius S, O'Donnell Christopher J, Vasan Ramachandran S, Wei Wei-Qi, Wilke Russell A, Liu Ching-Ti, Sun Fangui, Guo Xiuqing, Heckbert Susan R, Post Wendy, Sotoodehnia Nona, Arnold Alice M, Stafford Jeanette M, Ding Jingzhong, Herrington David M, Kritchevsky Stephen B, Eiriksdottir Gudny, Launer Leonore J, Harris Tamara B, Chu Audrey Y, Giulianini Franco, MacFadyen Jean G, Barratt Bryan J, Nyberg Fredrik, Stricker Bruno H, Uitterlinden André G, Hofman Albert, Rivadeneira Fernando, Emilsson Valur, Franco Oscar H, Ridker Paul M, Gudnason Vilmundur, Liu Yongmei, Denny Joshua C, Ballantyne Christie M, Rotter Jerome I, Adrienne Cupples L, Psaty Bruce M, Palmer Colin N A, Tardif Jean-Claude, Colhoun Helen M, Hitman Graham, Krauss Ronald M, Wouter Jukema J, Caulfield Mark J
СтатьяМетаанализПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАПеревод пока не подготовлен
Аннотация
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.
Для цитирования: Postmus Iris, Trompet Stella, Deshmukh Harshal A, Barnes Michael R, Li Xiaohui, Warren Helen R, Chasman Daniel I, Zhou Kaixin, Arsenault Benoit J, Donnelly Louise A, Wiggins Kerri L, Avery Christy L, Griffin Paula, Feng QiPing, Taylor Kent D, Li Guo, Evans Daniel S, Smith Albert V, de Keyser Catherine E, Johnson Andrew D, de Craen Anton J M, Stott David J, Buckley Brendan M, Ford Ian, Westendorp Rudi G J, Slagboom P Eline, Sattar Naveed, Munroe Patricia B, Sever Peter, Poulter Neil, Stanton Alice, Shields Denis C, O'Brien Eoin, Shaw-Hawkins Sue, Chen Y-D Ida, Nickerson Deborah A, Smith Joshua D, Dubé Marie Pierre, Boekholdt S Matthijs, Hovingh G Kees, Kastelein John J P, McKeigue Paul M, Betteridge John, Neil Andrew, Durrington Paul N, Doney Alex, Carr Fiona, Morris Andrew, McCarthy Mark I, Groop Leif, Ahlqvist Emma, Welcome Trust Case Control Consortium, Bis Joshua C, Rice Kenneth, Smith Nicholas L, Lumley Thomas, Whitsel Eric A, Stürmer Til, Boerwinkle Eric, Ngwa Julius S, O'Donnell Christopher J, Vasan Ramachandran S, Wei Wei-Qi, Wilke Russell A, Liu Ching-Ti, Sun Fangui, Guo Xiuqing, Heckbert Susan R, Post Wendy, Sotoodehnia Nona, Arnold Alice M, Stafford Jeanette M, Ding Jingzhong, Herrington David M, Kritchevsky Stephen B, Eiriksdottir Gudny, Launer Leonore J, Harris Tamara B, Chu Audrey Y, Giulianini Franco, MacFadyen Jean G, Barratt Bryan J, Nyberg Fredrik, Stricker Bruno H, Uitterlinden André G, Hofman Albert, Rivadeneira Fernando, Emilsson Valur, Franco Oscar H, Ridker Paul M, Gudnason Vilmundur, Liu Yongmei, Denny Joshua C, Ballantyne Christie M, Rotter Jerome I, Adrienne Cupples L, Psaty Bruce M, Palmer Colin N A, Tardif Jean-Claude, Colhoun Helen M, Hitman Graham, Krauss Ronald M, Wouter Jukema J, Caulfield Mark J. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.. Nature communications. 2014. DOI: 10.1038/ncomms6068.
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