The Tohoku journal of experimental medicine · 2021
Behçet's Disease with Extremely High Levels of Urinary β2-Microglobulin after Non-Steroidal Anti-Inflammatory Drug Treatment.
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Ogino Ryohei, Shimada Karin, Narai Daiki, Goto Masanori, Sato Katsuhiro, Katsuta Yoshihisa, Shiigi Akimasa, Ueda Juri, Oyama Chika, Fujikawa Yuko, Miyazawa Isabelle, Ohara Takahiro, Sumitomo Kazuhiro, Sato Shigeru, Koinuma Nobuo, Kanno Atsuhiro, Furukawa Katsutoshi
Аннотация
Behçet's disease is an inflammatory disease which manifests itself as various symptoms, such as uveitis, oral and genital aphthae, erythema nodosa, gastro-intestinal ulcerations and encephalopathy. Among the manifestations, renal dysfunction is reported in some percentage of the patients with this disorder. We experienced a middle-aged male with Behçet's disease who showed an extremely high level of urinary β2-microglulin, which is one of the markers of renal dysfunction, despite normal serum creatinine levels. The patient was on non-steroidal anti-inflammatory drug (NSAID) therapy for 7 weeks, and this could have affected his renal dysfunction. The present report suggests that renal injury should not be underestimated in patients with Behçet's disease, especially in patients using NSAIDs.