Journal of nephrology · 2012
Total parathyroidectomy improves survival of hemodialysis patients with secondary hyperparathyroidism.
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Iwamoto Noriyuki, Sato Nodoka, Nishida Masaya, Hashimoto Tetsuya, Kobayashi Hiroyuki, Yamasaki Satoru, Ono Toshihiko, Nishimura Masato, Tokoro Toshiko, Sakoda Chikako, Murakawa Mayuko, Okino Koji, Okamoto Yuu, Imai Ryo, Adachi Naoto, Ninomiya Kanji, Mabuchi Hisao, Koyama Masaki, Nakanouchi Tsuneyuki, Iseki Kunitoshi
Аннотация
BACKGROUND AND AIMS: To compare the prognosis of chronic hemodialysis patients with or without parathyroidectomy.
METHODS: Among 158 chronic hemodialysis patients who underwent total parathyroidectomy between July 1998 and April 2009, 88 patients were matched with 88 controls for sex, age, underlying disease and prior dialysis history. Then a retrospective evaluation of their prognosis was performed over a median observation period of 4.41 years.
RESULTS: The overall survival rate was 90.4% in the parathyroidectomy group and 67.4% in the control group. The cardiovascular death-free survival rate was 94.6% in the parathyroidectomy group and 76.3% in the control group. During observation, intact parathyroid hormone was measured every 6 months, and its average serum level was 37 ± 92 ng/L in the total parathyroidectomy group versus 274 ± 233 ng/L in the control group (p=0.0001). The total parathyroidectomy group had a significantly lower corrected calcium level and higher serum albumin level. Multivariate analysis revealed that parathyroidectomy, atrial fibrillation and serum albumin were significant factors for both total and cardiovascular mortality.
CONCLUSION: Total parathyroidectomy was associated with better survival, probably due to decreased cardiovascular mortality.
METHODS: Among 158 chronic hemodialysis patients who underwent total parathyroidectomy between July 1998 and April 2009, 88 patients were matched with 88 controls for sex, age, underlying disease and prior dialysis history. Then a retrospective evaluation of their prognosis was performed over a median observation period of 4.41 years.
RESULTS: The overall survival rate was 90.4% in the parathyroidectomy group and 67.4% in the control group. The cardiovascular death-free survival rate was 94.6% in the parathyroidectomy group and 76.3% in the control group. During observation, intact parathyroid hormone was measured every 6 months, and its average serum level was 37 ± 92 ng/L in the total parathyroidectomy group versus 274 ± 233 ng/L in the control group (p=0.0001). The total parathyroidectomy group had a significantly lower corrected calcium level and higher serum albumin level. Multivariate analysis revealed that parathyroidectomy, atrial fibrillation and serum albumin were significant factors for both total and cardiovascular mortality.
CONCLUSION: Total parathyroidectomy was associated with better survival, probably due to decreased cardiovascular mortality.
Предметные рубрики MeSH
AdultAgedBiomarkersCalciumCardiovascular DiseasesDisease-Free SurvivalFemaleHumansHyperparathyroidism, SecondaryKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisParathyroid HormoneParathyroidectomyRenal DialysisRetrospective StudiesRisk AssessmentRisk FactorsSerum AlbuminSurvival RateTime FactorsTreatment Outcome