Journal of endodontics · 2025
The Effect of Systemic Statin Intake on Healing of Apical Periodontitis after Nonsurgical Root Canal Treatment: A Retrospective Cohort Study.
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Goel Esha, Mkhreb Shahrah, Cotti Elisabetta, Ideo Francesca, Niazi Sadia, Koller Garrit, Farzadi Samira, Mannocci Francesco
Аннотация
INTRODUCTION: This retrospective cohort study compared the radiographic healing of apical periodontitis following root canal treatments and retreatments in patients regularly taking statins versus those who had never taken statins.
METHODS: Patients who underwent root canal treatment or retreatment performed by undergraduate and postgraduate students were included. The patients were divided into 2 age-matched groups: those who reported regularly taking statins and those who had never taken statins. The outcome was assessed using periapical radiographs taken at least at 1-year post-treatment. Teeth with short root canal fillings were excluded. Single and multiple binary logistic regression tested the association between statin use and radiographic treatment outcome while adjusting for root-canal and restoration quality, diabetes mellitus, cardiovascular diseases, patient age, tooth type, and follow-up period.
RESULTS: A total of 122 teeth were analyzed: 62 from patients taking statins and 60 from patients not taking statins. Using lenient criteria, logistic regression showed no significant difference in healing rates between the statin and control groups (90.3% vs. 90%; OR = 1.04; P = .952). However, under strict criteria, patients taking statins had a significantly lower probability of success compared to controls (62.9% vs 85%; OR = 0.30; P = .008).
CONCLUSIONS: Patients taking statins had a lower number of radiographic complete healings than those not taking statins. The results of this study challenge the presumed benefits of systemic statins intake on AP healing.
METHODS: Patients who underwent root canal treatment or retreatment performed by undergraduate and postgraduate students were included. The patients were divided into 2 age-matched groups: those who reported regularly taking statins and those who had never taken statins. The outcome was assessed using periapical radiographs taken at least at 1-year post-treatment. Teeth with short root canal fillings were excluded. Single and multiple binary logistic regression tested the association between statin use and radiographic treatment outcome while adjusting for root-canal and restoration quality, diabetes mellitus, cardiovascular diseases, patient age, tooth type, and follow-up period.
RESULTS: A total of 122 teeth were analyzed: 62 from patients taking statins and 60 from patients not taking statins. Using lenient criteria, logistic regression showed no significant difference in healing rates between the statin and control groups (90.3% vs. 90%; OR = 1.04; P = .952). However, under strict criteria, patients taking statins had a significantly lower probability of success compared to controls (62.9% vs 85%; OR = 0.30; P = .008).
CONCLUSIONS: Patients taking statins had a lower number of radiographic complete healings than those not taking statins. The results of this study challenge the presumed benefits of systemic statins intake on AP healing.