Cephalalgia : an international journal of headache · 2011
Head tremor related to CACNA1A mutations.
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Geerlings Rianne P J, Koehler Peter J, Haane Danielle Y P, Stam Anine H, de Vries Boukje, Boon Elles M J, Haan Joost
Аннотация
INTRODUCTION: Familial hemiplegic migraine (FHM) is characterized by the familial occurrence of migraine attacks with fully reversible transient hemiplegia. Mutations in three different genes have been identified; CACNA1A (FHM1), ATP1A2 (FHM2) and SCN1A (FHM3). Besides hemiplegia, several other symptoms have been described in FHM 1-3 mutation carriers, including epilepsy and cerebellar symptoms.
CASE REPORT: We describe two patients in whom hemiplegic attacks were not the presenting symptom, but in whom an otherwise unexplained head tremor led us to search for FHM mutations. Both patients carried a mutation in the CACNA1A gene.
DISCUSSION: CACNA1A mutations can give significant symptoms other than (hemiplegic) migraine as reason for presentation.
CASE REPORT: We describe two patients in whom hemiplegic attacks were not the presenting symptom, but in whom an otherwise unexplained head tremor led us to search for FHM mutations. Both patients carried a mutation in the CACNA1A gene.
DISCUSSION: CACNA1A mutations can give significant symptoms other than (hemiplegic) migraine as reason for presentation.