European journal of neurology · 2011
Etiology and treatment of ischaemic stroke in patients with β-thalassemia major.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Vassilopoulou S, Anagnostou E, Paraskevas G, Spengos K
Аннотация
BACKGROUND AND PURPOSE: Although hypercoagulability-induced thromboembolism is generally accepted as cause of cerebral ischaemia in thalassemic patients, cardiogenic embolism has been recently suggested as another possible stroke etiology.
METHODS: We present four adult β-thalassemia major patients with manifest cardiac involvement who suffered territorial strokes.
RESULTS: In the presence of siderotoxic cardiomyopathy and arrhythmia, we assumed cardiogenic embolism as etiology of stroke and initiated oral anticoagulation as preventive medication. Two of our patients were the first β-thalassemia major patients who underwent successful thrombolysis with rtPA.
CONCLUSIONS: Cardioembolism seems to be the cause of stroke in cases of β-thalassemia major. Thrombolysis can be applied in the setting of acute brain ischaemia in such high risk patients.
METHODS: We present four adult β-thalassemia major patients with manifest cardiac involvement who suffered territorial strokes.
RESULTS: In the presence of siderotoxic cardiomyopathy and arrhythmia, we assumed cardiogenic embolism as etiology of stroke and initiated oral anticoagulation as preventive medication. Two of our patients were the first β-thalassemia major patients who underwent successful thrombolysis with rtPA.
CONCLUSIONS: Cardioembolism seems to be the cause of stroke in cases of β-thalassemia major. Thrombolysis can be applied in the setting of acute brain ischaemia in such high risk patients.
Предметные рубрики MeSH
AdultAnti-Arrhythmia AgentsAnticoagulantsAphasiaAtrial FibrillationBrain IschemiaCardiomyopathiesCardiomyopathy, DilatedChelation TherapyCombined Modality TherapyFemaleHemiplegiaHemosiderosisHumansInfarction, Middle Cerebral ArteryIntracranial EmbolismMaleSplenectomyThrombolytic TherapyTissue Plasminogen ActivatorTomography, X-Ray ComputedTransfusion Reactionbeta-Thalassemia