Medicine · 2026
Severe exfoliative dermatitis induced by apalutamide in a mHSPC patient: A case report.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Chen Hanzhong, Li Teng, Fan Junhong, Liu Jiumin
Аннотация
RATIONALE: Apalutamide is a generation androgen antagonist for the treatment of metastatic hormone sensitive prostate cancer and non-metastatic castration resistant prostate cancer. Skin adverse reactions caused by apalutamide are mostly rashes and maculopapules.
PATIENT CONCERNS: There are a few reports about exfoliative dermatitis caused by apalutamide.
DIAGNOSES: Severe exfoliative dermatitis induced by apalutamide.
INTERVENTIONS: Gamma globulin, cefoperazone sulbactam sodium, albumin, ebastine, loratadine, hydrocortisone cream, and 3% boric acid lotion.
OUTCOMES: Whole-body skin was red, without exudation, and with a small amount of desquamation.
LESSONS: The incidence of exfoliative dermatitis due to apalutamide is low but severe, and if a serious adverse skin reaction is suspected, apalutamide needs to be discontinued immediately and treated accordingly.
PATIENT CONCERNS: There are a few reports about exfoliative dermatitis caused by apalutamide.
DIAGNOSES: Severe exfoliative dermatitis induced by apalutamide.
INTERVENTIONS: Gamma globulin, cefoperazone sulbactam sodium, albumin, ebastine, loratadine, hydrocortisone cream, and 3% boric acid lotion.
OUTCOMES: Whole-body skin was red, without exudation, and with a small amount of desquamation.
LESSONS: The incidence of exfoliative dermatitis due to apalutamide is low but severe, and if a serious adverse skin reaction is suspected, apalutamide needs to be discontinued immediately and treated accordingly.