Severe exfoliative dermatitis induced by apalutamide in a mHSPC patient: A case report.

RATIONALE: Apalutamide is a generation androgen antagonist for the treatment of metastatic hormone sensitive prostate cancer and non-metastatic castration resistant prostate cancer. Skin adverse reactions caused by apalutamide are mostly rashes and maculopapules.

PATIENT CONCERNS: There are a few reports about exfoliative dermatitis caused by apalutamide.

DIAGNOSES: Severe exfoliative dermatitis induced by apalutamide.

INTERVENTIONS: Gamma globulin, cefoperazone sulbactam sodium, albumin, ebastine, loratadine, hydrocortisone cream, and 3% boric acid lotion.

OUTCOMES: Whole-body skin was red, without exudation, and with a small amount of desquamation.

LESSONS: The incidence of exfoliative dermatitis due to apalutamide is low but severe, and if a serious adverse skin reaction is suspected, apalutamide needs to be discontinued immediately and treated accordingly.