HERACLIS-PSC: Current characteristics of primary sclerosing cholangitis with or without inflammatory bowel disease in Greece-a national multicenter cohort study.
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Theodoros Voulgaris, Fotios Fousekis, Konstantinos Mousourakis, Euaggelos Cholongitas, Konstantinos Argyriou, George Michalopoulos, Konsantinos Tsitsigiannis, Paraskevi Fytili, Spyridon Michopoulos, Nikoletta Mathou, Olga Giouleme, Evangelina Vlahou, George Geramoutsos, Ioannis Drygiannakis, Pantelis Karatzas, Maria Tzouvala, Eirini Zacharopoulou, George Tribonias, Despoina Arna, Panagiota Ioannidou, Margarita Papatheodoridi, Christos Liatsos, Aggeliki Christidou, Evanthia Zampeli, Nikolaos Kyriakos, Dimitrios Ntailianas, Giorgos Bamias, Jiannis Vlachogiannakos, Andreas Kapsoritakis, Nikos Viazis, Dimitrios Christodoulou, George Papatheodoridis
Аннотация
AIM: To evaluate the epidemiological and clinical features and natural history of PSC in Greece, a southern European country.
METHODS: In the HERACLIS-PSC study, consecutive patients with PSC-IBD followed at Greek inflammatory bowel disease (IBD) centers were included and compared to data from consecutive patients with PSC-only followed at a Greek liver center.
RESULTS: Among PSC-IBD patients (n=112, males:56%), 62.5% had UC (pancolitis:76%), 35.7% Crohn's disease and 1.8% indeterminate colitis. PSC was diagnosed at a younger age in PSC-IBD than PSC-only patients (n=39; males:54%) (32±15 vs 40±15 years; p=0.007), while the two groups did not differ significantly in gender, extrahepatic bile duct involvement, or development of cirrhosis, cholangiocarcinoma or CRC, although CRC occurred only in PSC-IBD (n=8). Transplant-free survival was higher in PSC-IBD than PSC-only (5-/10-year:95%/87% vs 85%/77%; p=0.021), while older age at PSC diagnosis and cirrhosis development were independently associated with lower transplant-free survival.
CONCLUSION: In Greece, PSC-IBD patients are usually males with UC, in whom PSC is diagnosed at a younger age demonstrating better transplant-free survival, compared to PSC-only.