Journal of the American College of Cardiology · 2007
Valve-in-a-valve concept for transcatheter minimally invasive repeat xenograft implantation.
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Walther Thomas, Falk Volkmar, Dewey Todd, Kempfert Jörg, Emrich Fabian, Pfannmüller Bettina, Bröske Petra, Borger Michael A, Schuler Gerhard, Mack Michael, Mohr Friedrich W
Аннотация
OBJECTIVES: This study sought to evaluate the feasibility of minimally invasive transapical repeat valve-in-a-valve (VinV) implantation.
BACKGROUND: Reoperative heart valve replacement for degenerated xenografts is associated with an increased surgical risk.
METHODS: Conventional Carpentier Edwards porcine aortic (n = 5) and mitral (n = 2) valve prostheses were implanted in 7 pigs. Transapical VinV implantation of a pericardial xenograft fixed within a 23-mm stainless steel, balloon expandable stent (Cribier Edwards, Edwards Lifesciences, Irvine, California) was then performed under fluoroscopic and echocardiographic visualization on the beating heart with ventricular unloading via cardiopulmonary bypass and rapid ventricular pacing.
RESULTS: Valve deployment was successfully performed in all cases. The radiopaque marking within the stent of the conventional aortic or mitral xenograft allowed for optimal positioning of the stent-delivered valve. All valves were firmly positioned without any migration. There were neither paravalvular nor transvalvular leaks, and good hemodynamic function was observed in all cases. All coronary arteries remained patent. Positioning and function were confirmed by autopsy in all animals.
CONCLUSIONS: The VinV concept is promising for minimally invasive beating heart repeat aortic or mitral valve replacement, using a stent-fixed sutureless prosthesis.
BACKGROUND: Reoperative heart valve replacement for degenerated xenografts is associated with an increased surgical risk.
METHODS: Conventional Carpentier Edwards porcine aortic (n = 5) and mitral (n = 2) valve prostheses were implanted in 7 pigs. Transapical VinV implantation of a pericardial xenograft fixed within a 23-mm stainless steel, balloon expandable stent (Cribier Edwards, Edwards Lifesciences, Irvine, California) was then performed under fluoroscopic and echocardiographic visualization on the beating heart with ventricular unloading via cardiopulmonary bypass and rapid ventricular pacing.
RESULTS: Valve deployment was successfully performed in all cases. The radiopaque marking within the stent of the conventional aortic or mitral xenograft allowed for optimal positioning of the stent-delivered valve. All valves were firmly positioned without any migration. There were neither paravalvular nor transvalvular leaks, and good hemodynamic function was observed in all cases. All coronary arteries remained patent. Positioning and function were confirmed by autopsy in all animals.
CONCLUSIONS: The VinV concept is promising for minimally invasive beating heart repeat aortic or mitral valve replacement, using a stent-fixed sutureless prosthesis.
Предметные рубрики MeSH
AnimalsAortic ValveBioprosthesisCardiac CatheterizationCardiopulmonary BypassDisease Models, AnimalFeasibility StudiesHeart Valve Prosthesis ImplantationMinimally Invasive Surgical ProceduresMonitoring, IntraoperativeProsthesis FailureReoperationRisk FactorsSensitivity and SpecificitySus scrofaTransplantation, Heterologous