The American journal of tropical medicine and hygiene · 2012
An assessment of the genetic diversity of Leishmania infantum isolates from infected dogs in Brazil.
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Batista Luís Fábio da S, Segatto Marcela, Guedes Carlos Eduardo S, Sousa Rosana S, Rodrigues Cleusa A T, Brazuna Júlia Cristina M, Silva Joselli S, Santos Silvana O, Larangeira Daniela, Macedo Andréa Mara, Schriefer Albert, Veras Patrícia S T
Аннотация
Correlations between the genetic diversity of Leishmania infantum (syn. L. chagasi) isolates and their respective geographic origins support the theoretic assumption that visceral leishmaniasis probably originated in the Old World. Because dogs are widely considered to be the main reservoir of this disease, the present study aimed to investigate the degree of genetic divergence among 44 leishmanial canine isolates from two Brazilian cities, Jequié and Campo Grande, located approximately 2,028 km from each other. We hypothesized that a low degree of genetic divergence would be observed among these isolates. In fact, statistical analyses found no significant differences between the isolates using both random amplified polymorphic DNA and multilocus microsatellite typing genotyping techniques with three and seven markers, respectively. These findings provide support for the recent introduction of L. infantum into the New World.