Focal Epilepsy in Individuals with Laron Syndrome.

OBJECTIVE

The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS).

METHODS

Data were retrieved from medical records of a single-center cohort of 75 patients with LS.

RESULTS

We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications.

CONCLUSION

Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.