Lasers in surgery and medicine · 2026
Clinical Outcomes of Fractional Carbon Dioxide Laser Treatment in Women With Vulvar Lichen Simplex Chronicus: A Retrospective Study With 12-Month Follow-Up.
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Wu Nengxiu, Chen Siai, Lin Chaoqin, Wang Qi
Аннотация
OBJECTIVE: To evaluate the efficacy and safety of fractional carbon dioxide (CO2) laser therapy in women with vulvar lichen simplex chronicus (VLSC).
METHODS: This retrospective study included 88 women with VLSC who underwent three sessions of fractional CO2 laser treatment between January 2022 and January 2024. Clinical outcomes were assessed using the Cattaneo clinical symptom and sign scoring system to calculate the therapeutic efficacy index. Vulvar pruritus and dyspareunia were evaluated using a visual analog scale (VAS), and patient-reported global improvement was assessed with the Patient Global Impression of Change (PGI-C) questionnaire. Follow-up assessments were conducted at 1, 6, and 12 months after treatment.
RESULTS: At 1, 6, and 12 months post-treatment, significant reductions were observed in VAS scores for vulvar pruritus and dyspareunia, as well as in Cattaneo clinical symptom and sign scores (all p < 0.05). The overall response rates were 89.8% (79/88; 95% confidence interval [CI], 81.7%-94.5%), 93.2% (82/88; 95% CI, 85.9%-96.8%), and 88.6% (78/88; 95% CI, 80.3%-93.7%), respectively. According to the PGI-C questionnaire, the proportions of patients reporting improvement or marked improvement were 72.7%, 78.4%, and 70.5% at the corresponding follow-up time points. No significant differences in treatment outcomes were observed according to disease duration or menopausal status.
CONCLUSION: Fractional CO2 laser therapy was associated with significant and sustained improvement in clinical symptoms and signs of VLSC, suggesting that it may represent a promising therapeutic option for selected women with VLSC.
METHODS: This retrospective study included 88 women with VLSC who underwent three sessions of fractional CO2 laser treatment between January 2022 and January 2024. Clinical outcomes were assessed using the Cattaneo clinical symptom and sign scoring system to calculate the therapeutic efficacy index. Vulvar pruritus and dyspareunia were evaluated using a visual analog scale (VAS), and patient-reported global improvement was assessed with the Patient Global Impression of Change (PGI-C) questionnaire. Follow-up assessments were conducted at 1, 6, and 12 months after treatment.
RESULTS: At 1, 6, and 12 months post-treatment, significant reductions were observed in VAS scores for vulvar pruritus and dyspareunia, as well as in Cattaneo clinical symptom and sign scores (all p < 0.05). The overall response rates were 89.8% (79/88; 95% confidence interval [CI], 81.7%-94.5%), 93.2% (82/88; 95% CI, 85.9%-96.8%), and 88.6% (78/88; 95% CI, 80.3%-93.7%), respectively. According to the PGI-C questionnaire, the proportions of patients reporting improvement or marked improvement were 72.7%, 78.4%, and 70.5% at the corresponding follow-up time points. No significant differences in treatment outcomes were observed according to disease duration or menopausal status.
CONCLUSION: Fractional CO2 laser therapy was associated with significant and sustained improvement in clinical symptoms and signs of VLSC, suggesting that it may represent a promising therapeutic option for selected women with VLSC.