The British journal of ophthalmology · 2026
Does secondary intraocular lens implantation increase the risk of glaucoma in aphakic patients who underwent cataract surgery in childhood?
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Barnett Victoria, Ashton Christopher, Barker Lucy
Аннотация
BACKGROUND/AIMS: Secondary intraocular lens (IOL) implantation is reported to increase glaucoma development and progression in paediatric patients. We evaluated the risk of new-onset glaucoma or progression following secondary IOL implantation in children and young adults.
METHODS: Retrospective cohort study of secondary IOL implantation following paediatric cataract surgery at Moorfields Eye Hospital (2017-2025). Anterior chamber IOLs or retinal pathology were excluded. Primary outcome was glaucoma progression (worsening optic disc appearance, sustained intraocular pressure (IOP) elevation requiring medical therapy escalation and/or glaucoma surgery). Secondary outcomes included longitudinal IOP trends and best-corrected visual acuity.
RESULTS: 57 eyes were included (30 paediatric, 0-16 years; 27 young adult, 17-30 years); mean follow-up 28.2 months (SD±26.4). Aetiology was congenital (49%), uveitic (26%) and traumatic (25%). IOL position was ciliary sulcus (68%), capsular bag (18%) and scleral-fixated (14%). Glaucoma progression occurred in 16 eyes (28%), predominantly in eyes with pre-existing glaucoma (15/21, 71%), vs 1/36 eyes (3%) without pre-existing glaucoma (relative risk 25.7; 95% CI 3.7 to 181.0; p<0.0001). Progression was most frequent in uveitic eyes (67%) and was not observed in traumatic cataract (p=0.00012). No significant association was observed between age group or IOL position and glaucoma progression.
CONCLUSIONS: Secondary IOL implantation is associated with a significant risk of glaucoma progression in eyes with pre-existing glaucoma but appears unlikely to induce new-onset glaucoma in eyes without prior disease. These findings highlight the importance of careful patient selection, counselling and close postoperative surveillance in patients with pre-existing glaucoma undergoing secondary IOL implantation.
METHODS: Retrospective cohort study of secondary IOL implantation following paediatric cataract surgery at Moorfields Eye Hospital (2017-2025). Anterior chamber IOLs or retinal pathology were excluded. Primary outcome was glaucoma progression (worsening optic disc appearance, sustained intraocular pressure (IOP) elevation requiring medical therapy escalation and/or glaucoma surgery). Secondary outcomes included longitudinal IOP trends and best-corrected visual acuity.
RESULTS: 57 eyes were included (30 paediatric, 0-16 years; 27 young adult, 17-30 years); mean follow-up 28.2 months (SD±26.4). Aetiology was congenital (49%), uveitic (26%) and traumatic (25%). IOL position was ciliary sulcus (68%), capsular bag (18%) and scleral-fixated (14%). Glaucoma progression occurred in 16 eyes (28%), predominantly in eyes with pre-existing glaucoma (15/21, 71%), vs 1/36 eyes (3%) without pre-existing glaucoma (relative risk 25.7; 95% CI 3.7 to 181.0; p<0.0001). Progression was most frequent in uveitic eyes (67%) and was not observed in traumatic cataract (p=0.00012). No significant association was observed between age group or IOL position and glaucoma progression.
CONCLUSIONS: Secondary IOL implantation is associated with a significant risk of glaucoma progression in eyes with pre-existing glaucoma but appears unlikely to induce new-onset glaucoma in eyes without prior disease. These findings highlight the importance of careful patient selection, counselling and close postoperative surveillance in patients with pre-existing glaucoma undergoing secondary IOL implantation.