Short- and long-term relationships between neurocognitive performance and general function in bipolar disorder.

Bipolar disorder (BD) is associated with significant impairment in multiple domains of function that often persists after clinical recovery. Current literature suggests that neurocognitive function may contribute to functional impairment in adult populations (18-60 years). However, literature in this area is heterogeneous, and no consistent correlations have been found between neurocognitive domains and general function. This review examines literature on the cross-sectional and longitudinal relationships between neurocognitive function and general function restricted to BD aiming to clarify the symptomatic and prognostic relationships between the two important clinical domains.