Can Clinical and Surgical Parameters Be Combined to Predict How Long It Will Take a Tibia Fracture to Heal? A Prospective Multicentre Observational Study: The FRACTING Study.
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Massari Leo, Benazzo Francesco, Falez Francesco, Cadossi Ruggero, Perugia Dario, Pietrogrande Luca, Aloj Domenico Costantino, Capone Antonio, D'Arienzo Michele, Cadossi Matteo, Lorusso Vincenzo, Caruso Gaetano, Ghiara Matteo, Ciolli Luigi, La Cava Filippo, Guidi Marco, Castoldi Filippo, Marongiu Giuseppe, La Gattuta Alessandra, Dell'Omo Dario, Scaglione Michelangelo, Giannini Sandro, Fortina Mattia, Riva Alberto, De Palma Pier Luigi, Gigante Antonio Pompilio, Moretti Biagio, Solarino Giuseppe, Lijoi Francesco, Giordano Giovanni, Londini Pier Giorgio, Castellano Danilo, Sessa Giuseppe, Costarella Luciano, Barile Antonio, Borrelli Mariano, Rota Attilio, Fontana Raffaele, Momoli Alberto, Micaglio Andrea, Bassi Guido, Cornacchia Rossano Stefano, Castelli Claudio, Giudici Michele, Monesi Mauro, Branca Vergano Luigi, Maniscalco Pietro, Bulabula M'Putu, Zottola Vincenzo, Caraffa Auro, Antinolfi Pierluigi, Catani Fabio, Severino Claudio, Castaman Enrico, Scialabba Carmelo, Tovaglia Venceslao, Corsi Pietro, Friemel Paolo, Ranellucci Marco, Caiaffa Vincenzo, Maraglino Giovanni, Rossi Roberto, Pastrone Antonio, Caldora Patrizio, Cusumano Claudio, Squarzina Pier Bruno, Baschieri Ugo, Demattè Ettore, Gherardi Stefano, De Roberto Carlo, Belluati Alberto, Giannini Antonio, Villani Ciro, Persiani Pietro, Demitri Silvio, Di Maggio Bruno, Abate Guglielmo, De Terlizzi Francesca, Setti Stefania
Аннотация
METHODS: The study included 363 patients. Information on patient health, fracture morphology, and surgical treatment adopted were combined to calculate the FRACTING score. Fractures were considered healed when the patient was able to fully weight-bear without pain.
RESULTS: 319 fractures (88%) healed within 12 months from treatment. Forty-four fractures healed after 12 months or underwent a second surgery. FRACTING score positively correlated with days to healing: r = 0.63 (p < 0.0001). Average score value was 7.3 ± 2.5; ROC analysis showed strong reliability of the score in separating patients healing before versus after 6 months: AUC = 0.823.
CONCLUSIONS: This study shows that the FRACTING score can be employed both to predict months needed for fracture healing and to identify immediately after treatment patients at risk of prolonged healing. In patients with high score values, new pharmacological and nonpharmacological treatments to enhance osteogenesis could be tested selectively, which may finally result in reduced disability time and health cost savings.